WP3 aims to achieve several objectives related to how megatrends impact the labour market participation, mental health, and overall well-being of individuals. The first objective is to quantify this impact, while the second objective is to zoom in on groups of workers who are particularly vulnerable to these changes. The COVID-19 pandemic has had a significant impact on teleworkers’ outcomes, and WP3 aims to draw lessons from this experience as a third objective. The fourth objective is to determine the impact on individuals based on their specific characteristics as employees. Finally, WP3 will evaluate the role of different institutional and policy settings in national labour markets that contribute to the heterogeneous nature of the impact of megatrends. By meeting these objectives, WP3 will generate important insights into the complex interplay between megatrends and the labour market, which can help inform policies and interventions to support individuals’ well-being and workforce participation.